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Beacon Hill Life Sciences is seeking a Research Scientist/Sr Research Scientist with extensive expertise in mass spectrometry-based bioanalysis, protein/peptide characterization, and analytical assay development to join client's team.

The successful candidate will contribute to bioanalytical method development, validation, and large-scale study support across discovery and clinical programs, with a strong focus on LC-MS/MS (MRM), Immunoprecipitation, and complementary biochemical techniques.

Key Responsibilities:

• Lead the development, optimization, and validation of LC-MS/MS assays (MRM mode) and IP assay for quantification of biomarkers, proteins, peptides, cytokines, and metabolites.
• Design and execute workflows for peptide mapping, post-translational modification (PTM) analysis, disulfide bond mapping, and glycosylation analysis.
• Develop fit-for-purpose bioanalytical methods for proteins with complex attributes (e.g., high MW, high glycosylation, unexpected MWs) using advanced enzymatic digestion strategies (deglycosylation, limited proteolysis).
• Support cross-functional groups including expression, reagent, and engineering teams by providing detailed biochemical and analytical characterization of proteins and reagents.
• Conduct advanced data processing and statistical analysis using multiple software from different vendors
• Instrument maintenance and troubleshooting
• Author technical reports, SOP, Electronic notebook

Qualifications:

• Minimum of 5~8 years of relevant industry experience, or 3~5 years with a PhD
• Extensive experience with mass spectrometry analysis of proteins and peptides (QTRAP, Q-TOF, MALDI-TOF, Orbitrap Fusion/Lumos, QQQ with MRM method)
• Demonstrated expertise in bioanalytical method development and validation for small and large molecules
• Perform intact and subunit protein mass spectrometry analysis, including characterization of monoclonal antibodies, fusion proteins, and bispecific/trispecific biologics
• Strong working knowledge biochemical assays (enzyme assays, colorimetric assays).
• Hands-on experience with a range of chromatography techniques RP-HPLC, SEC, HILIC, nanoLC, microLC).
• Proficient in wet lab sample preparation techniques (SPE, IP, LLE)

Work Environment:

• Laboratory-based position (based in Cambridge)
• Fast-paced environment
• Collaboration with cross-functional R&D and bioanalytical teams.

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