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Beacon Hill Life Sciences is looking for a Research Scientist who will play a critical role in the design, execution, and analysis of in vitro and ex vivo assays aimed at characterizing ion channel modulators. The role requires deep hands-on experience with cell-based assay technologies, supporting ion channel-focused drug discovery programs.
Key Responsibilities:
- Perform routine mammalian tissue culture (cell lines and neuronal cultures), including neuronal differentiation and maintenance of iPSC-derived neuronal models.
- Harvest rodent tissues, dissect specific brain regions, and prepare samples for downstream applications.
- Design and execute manual patch-clamp, automated patch-clamp (APC), and/or multi-electrode array (MEA) experiments to evaluate ion channel modulators in recombinant cell lines, primary neurons, and iPSC-derived neurons.
- Analyze, interpret, and present experimental data in internal team meetings and contribute to technical reports and data packages.
- Maintain meticulous lab records, adhere to SOPs and lab safety regulation guidelines, and ensure high data integrity and reproducibility.
Required Qualifications:
- BS/MS in Neuroscience, Pharmacology, Physiology, Cell Biology, or a related field.
- Minimum 3 years of hands-on experience in vitro pharmacology in academic, biotech, or pharmaceutical settings.
- Strong background in mammalian cell culture, including primary and iPSC-derived neurons.
- Experience with tissue harvesting, brain region dissection, and processing of neural tissue.
- Experience in manual patch-clamp electrophysiology, automated patch-clamp electrophysiology (APC), multielectrode array (MEA), or ELISA techniques is strongly preferred.
LSNJN1418398AB_1747774065